Methemoglobinemija uzrokovana akcidentalnom intoksikacijom metolaklorom i metobromuronom
| Autor: | Branimir Anić, Stjepko Pleština, Radovan Radonić, Marina Vidović, Dubravka Bosnić |
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| Jazyk: | chorvatština |
| Rok vydání: | 1999 |
| Předmět: | |
| Zdroj: | Arhiv za higijenu rada i toksikologiju Volume 50 Issue 2 |
| ISSN: | 1848-6312 0004-1254 |
| Popis: | An 81-year-old man was admitted in the emergency department approximately four hours after accidental ingestion of an unknown quantity of herbicide »Galex 500 EC«. This product contains 25% of metolachlor and 25% of metobromuron dissolved in xylene. In spite of the fact that the combination of aniline and urea-substituted derivatives is widely used in agriculture as herbicide, there are very few data available about their harmful effects on humans. These agents appear to be mildly toxic, and rarely has a major systemic effect been reported after the poisoning. On admittance, our patient showed remarkable cyanosis and his methaemoglobin level was 38.4% of the total haemoglobin, rising next day to 46.2%. Only mild transient signs of hypoxic effects on central nervous system were observed and the laboratory findings indicated mild haemolysis. Methylene blue was applied intravenously in a dose of 1.5 mg/kg (10 ml, 1% solution) on the second day of admission. Administration of methylene blue was very effective and the patient was discharged from the hospital fully recovered. U radu je prikazano otrovanje metolaklorom i metobromuronom, nastalo nakon slučajne ingestije nepoznate količine kombiniranog herbicida »Galex 500 EC«. Unatoč širokoj primjeni herbicida iz skupine anilida i derivata ureje, nema mnogo podataka o njihovu učinku na ljude. Otrovanja su rijetka zbog njihove relativno niske akutne toksičnosti. U našeg bolesnika kliničkom je slikom dominirala cijanoza, uz methemoglobinemiju koja je premašila 46% vrijednosti ukupnog hemoglobina, što je indiciralo intravensku primjenu 10 ml 1%-tne otopine metilenskog modrila (1,5 mg/kg). Učinak takve terapije bio je vrlo povoljan, cijanoza i znakovi hipoksije središnjega živčanog sustava ubrzo su nestali. Znakova lezije parenhimnih organa nije bilo, a laboratorijski se mogla uočiti blaža hemoliza. Bolesnik je nakon 12 dana otpušten bez trajnih posljedica otrovanja. |
| Databáze: | OpenAIRE |
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