| Autor: |
Gavrilov, Yury V., Ellison, Brian A., Yamamoto, Mihoko, Reddy, Hasini, Haybaeck, Johannes, Mignot, Emmanuel, Baumann, Christian R., Scammell, Thomas E., Valko, Philipp O. |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
Study Objectives: To examine the integrity of sleep-promoting neurons of the ventrolateral preoptic nucleus (VLPO) in postmortem brains of narcolepsy type 1 patients. Methods: Postmortem examination of five narcolepsy and eight control brains. Results: VLPO galanin neuron count did not differ between narcolepsy patients (11,151 ± 3,656) and controls (13,526 ± 9,544). Conclusions: A normal number of galanin-immunoreactive VLPO neurons in narcolepsy type 1 brains at autopsy suggests that VLPO cell loss is an unlikely explanation for the sleep fragmentation that often accompanies the disease. Significance Sleep fragmentation is common in narcolepsy type 1 but difficult to explain by orexin deficiency alone. As elderly people with fragmented sleep have a loss of sleep-promoting galanin neurons in the ventrolateral preoptic area (VLPO), we examined the VLPO in people with narcolepsy type 1. We found a normal number of galanin VLPO neurons, suggesting that the fragmented sleep of narcolepsy must arise from another cause. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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