| Autor: |
Hinton, Jonathan, Augustine, Maclyn, Gabara, Lavinia, Mariathas, Mark, Allan, Rick, Borca, Florina, Nicholas, Zoe, Gillett, Neil, Kwok, Chun Shing, Cook, Paul, Grocott, Michael P.W., Mamas, Mamas A., Curzen, Nicholas |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Popis: |
The aim of this study was to assess whether high sensitivity troponin (hs-cTnI) is associated with 1 year mortality in critical care (CC). One year mortality data were obtained from NHS Digital for a consecutive cohort of patients admitted to general CC unit (GCCU) and neuroscience CC unit (NCCU) who had hs-cTnI tests performed throughout their CC admission, regardless of whether the test was clinically indicated. Cox proportional hazards were used to estimate the risk of 1-year mortality. A landmark analysis was undertaken to assess whether any relationship at 1 year was driven by mortality within the first 30 days. A total of 1033 consecutive patients were included. At 1 year 254 (24.6%) patients had died. The admission log(10)hs-cTnI concentration in the entire cohort (HR 1.35 (95% CI 1.05–1.75) p = 0.009 with a bootstrap of 1000 samples) was independently associated with 1 year mortality. On landmark analysis the association with 1 year mortality was driven by 30 day mortality. These results indicate that admission hs-cTnI concentration is independently associated with 1 year mortality in CC and this relationship may be driven by differences in mortality at 30 days. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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