Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease

Autor: Finkbeiner, Steven, Tóth, G, Gardai, SJ, Zago, W, Bertoncini, CW, Cremades, N, Roy, SL, Tambe, MA, Rochet, J-C, Galvagnion, C, Skibinski, G
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Finkbeiner, Steven; Tóth, G; Gardai, SJ; Zago, W; Bertoncini, CW; Cremades, N; et al.(2014). Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease.. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/7w21r6n4
Popis: The misfolding of intrinsically disordered proteins such as α-synuclein, tau and the Aβ peptide has been associated with many highly debilitating neurodegenerative syndromes including Parkinson's and Alzheimer's diseases. Therapeutic targeting of the monom
Databáze: OpenAIRE