Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 100 Luo infants from the Boro area of Nyanza Province, Kenya
| Autor: | Arlehamn, Cecilia S Lindestam, Copin, Richard, Leary, Shay, Mack, Steven J, Phillips, Elizabeth, Mallal, Simon, Sette, Alessandro, Blatner, Gretta, Siefers, Heather, Ernst, Joel D, TBRU-ASTRa Study Team |
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| Rok vydání: | 2017 |
| Předmět: |
Genotype
Nucleic Acid Histocompatibility Testing Population Immunology Infant DNA Kenya Linkage Disequilibrium HLA alleles Databases Infectious Diseases Rare Diseases Good Health and Well Being Gene Frequency Genetic HLA Antigens Clinical Research Genetics Humans Tuberculosis TBRU-ASTRa Study Team Luo Polymorphism Sequence Analysis |
| Zdroj: | Human immunology, vol 78, iss 4 |
| Popis: | One hundred healthy infants enrolled as controls in a tuberculosis vaccine study in Nyanza Province, Kenya provided anonymized samples for DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, -DRB1, and -DRB3/4/5 loci. The purpose of the study was to characterize allele frequencies in the local population, to support studies of T cell immunity against pathogens, including Mycobacterium tuberculosis. There are no detectable deviations from Hardy Weinberg proportions for the HLA-B, -C, -DRB1, -DPB1, -DQA1 and -DQB1 loci. A minor deviation was detected at the HLA-A locus due to an excess of HLA-A*02:02, 29:02, 30:02, and 68:02 homozygotes. The genotype data are available in the Allele Frequencies Net Database under identifier 3393. |
| Databáze: | OpenAIRE |
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