Development of Injectable Amniotic Membrane Matrix for Postmyocardial Infarction Tissue Repair
| Autor: | Henry, Jeffrey JD, Delrosario, Lawrence, Fang, Jun, Wong, Sze Yue, Fang, Qizhi, Sievers, Richard, Kotha, Surya, Wang, Aijun, Farmer, Diana, Janaswamy, Praneeth, Lee, Randall J, Li, Song |
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| Rok vydání: | 2020 |
| Předmět: |
Cardiotonic Agents
Cells Medical Biotechnology Myocardial Infarction Biomedical Engineering Bioengineering Cardiovascular Regenerative Medicine Injections Medicinal and Biomolecular Chemistry Pregnancy Materials Testing Animals Humans Amnion hydrogels Heart Disease - Coronary Heart Disease Glycosaminoglycans Cultured Tissue Engineering 5.2 Cellular and gene therapies Myocardium Epithelial Cells Fibrosis Extracellular Matrix Rats myocardial infarctions Heart Disease Cattle Female amniotic membranes decellularization Sprague-Dawley Collagen Development of treatments and therapeutic interventions |
| Zdroj: | Advanced healthcare materials, vol 9, iss 2 |
| Popis: | Ischemic heart disease represents the leading cause of death worldwide. Heart failure following myocardial infarction (MI) is associated with severe fibrosis formation and cardiac remodeling. Recently, injectable hydrogels have emerged as a promising approach to repair the infarcted heart and improve heart function through minimally invasive administration. Here, a novel injectable human amniotic membrane (hAM) matrix is developed to enhance cardiac regeneration following MI. Human amniotic membrane is isolated from human placenta and engineered to be a thermoresponsive, injectable gel around body temperature. Ultrasound-guided injection of hAM matrix into rat MI hearts significantly improves cardiac contractility, as measured by ejection fraction (EF), and decrease fibrosis. The results of this study demonstrate the feasibility of engineering as an injectable hAM matrix and its efficacy in attenuating degenerative changes in cardiac function following MI, which may have broad applications in tissue regeneration. |
| Databáze: | OpenAIRE |
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