Relationship of regional brain β-amyloid to gait speed
| Autor: | Del Campo, Natalia, Payoux, Pierre, Djilali, Adel, Delrieu, Julien, Hoogendijk, Emiel O, Rolland, Yves, Cesari, Matteo, Weiner, Michael W, Andrieu, Sandrine, Vellas, Bruno, MAPT/DSA Study Group |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Aging Clinical Sciences Neurodegenerative Alzheimer's Disease Alzheimer Disease Clinical Research 80 and over Acquired Cognitive Impairment Humans Gait Aged Amyloid beta-Peptides Neurology & Neurosurgery Prevention Neurosciences Brain Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) MAPT/DSA Study Group Brain Disorders Cross-Sectional Studies Positron-Emission Tomography Neurological Biomedical Imaging Female Dementia Cognitive Sciences |
| Zdroj: | Neurology, vol 86, iss 1 |
| Popis: | ObjectiveTo investigate in vivo the relationship of regional brain β-amyloid (Aβ) to gait speed in a group of elderly individuals at high risk for dementia.MethodsCross-sectional associations between brain Aβ as measured with [18F]florbetapir PET and gait speed were examined in 128 elderly participants. Subjects ranged from healthy to mildly cognitively impaired enrolled in the control arm of the multidomain intervention in the Multidomain Alzheimer Preventive Trial (MAPT). Nearly all participants presented spontaneous memory complaints. Regional [18F]florbetapir (AV45) standardized uptake volume ratios were obtained via semiautomated quantitative analysis using the cerebellum as reference region. Gait speed was measured by timing participants while they walked 4 meters. Associations were explored with linear regression, correcting for age, sex, education, body mass index (BMI), and APOE genotype.ResultsWe found a significant association between Aβ in the posterior and anterior putamen, occipital cortex, precuneus, and anterior cingulate and slow gait speed (all corrected p < 0.05). A multivariate model emphasized the locations of the posterior putamen and the precuneus. Aβ burden explained up to 9% of the variance in gait speed, and significantly improved regression models already containing demographic variables, BMI, and APOE status.ConclusionsThe present PET study confirms, in vivo, previous postmortem evidence showing an association between Alzheimer disease (AD) pathology and gait speed, and provides additional evidence on potential regional effects of brain Aβ on motor function. More research is needed to elucidate the neural mechanisms underlying these regional associations, which may involve motor and sensorimotor circuits hitherto largely neglected in the pathophysiology of AD. |
| Databáze: | OpenAIRE |
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