Helicobacter pylori Chronic-Stage Inflammation Undergoes Fluctuations That Are Altered in tlpA Mutants
| Autor: | Johnson, Kevin S, Yang, Christina, Carter, J Elliot, Worthington, Atesh K, Robinson, Elektra K, Lopez-Magaña, Raymond, Salgado, Frida, Arnold, Isabelle, Ottemann, Karen M |
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| Přispěvatelé: | Freitag, Nancy E |
| Rok vydání: | 2023 |
| Předmět: |
Inflammation
Helicobacter pylori Agricultural and Veterinary Sciences Chemotaxis Digestive Diseases - (Peptic Ulcer) Biological Sciences chronic infection chemoreceptors gastric Medical and Health Sciences Microbiology Helicobacter Infections Mice Emerging Infectious Diseases Infectious Diseases Bacterial Proteins Gastric Mucosa Gastritis Animals 2.1 Biological and endogenous factors gut inflammation chemotaxis Aetiology Digestive Diseases Infection |
| Zdroj: | Infection and immunity, vol 91, iss 1 |
| Popis: | Helicobacter pylori colonizes half of the world's population and is responsible for a significant disease burden by causing gastritis, peptic ulcers, and gastric cancer. The development of host inflammation drives these diseases, but there are still open questions in the field about how H. pylori controls this process. We characterized H. pylori inflammation using an 8-month mouse infection time course and comparison of the wild type (WT) and a previously identified mutant lacking the TlpA chemoreceptor that causes elevated inflammation. Our work shows that H. pylori chronic-stage corpus inflammation undergoes surprising fluctuations, with changes in Th17 and eosinophil numbers. The H. pylori tlpA mutant changed the inflammation temporal characteristics, resulting in different inflammation from the wild type at some time points. tlpA mutants have equivalent total and gland colonization in late-stage infections. During early infection, in contrast, they show elevated gland and total colonization compared to those by WT. Our results suggest the chronic inflammation setting is dynamic and may be influenced by colonization properties of early infection. |
| Databáze: | OpenAIRE |
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