Microfluidic affinity and ChIP-seq analyses converge on a conserved FOXP2-binding motif in chimp and human, which enables the detection of evolutionarily novel targets

Autor: Li, Hao, Derisi, Joseph, Nelson, CS, Fuller, CK, Fordyce, PM, Greninger, AL, DeRisi, JL
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Li, Hao; Derisi, Joseph; Nelson, CS; Fuller, CK; Fordyce, PM; Greninger, AL; et al.(2013). Microfluidic affinity and ChIP-seq analyses converge on a conserved FOXP2-binding motif in chimp and human, which enables the detection of evolutionarily novel targets. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/2g6009qw
Popis: The transcription factor forkhead box P2 (FOXP2) is believed to be important in the evolution of human speech. A mutation in its DNA-binding domain causes severe speech impairment. Humans have acquired two coding changes relative to the conserved mammalian
Databáze: OpenAIRE