| Autor: |
Park, CC, Ahn, S, Bloom, JS, Lin, A, Wang, RT, Wu, T, Sekar, A, Khan, AH, Farr, CJ, Lusis, AJ, Leahy, RM, Lange, K, Smith, DJ |
| Jazyk: |
angličtina |
| Rok vydání: |
2008 |
| Zdroj: |
Park, CC; Ahn, S; Bloom, JS; Lin, A; Wang, RT; Wu, T; et al.(2008). Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids. Nature Genetics, 40(4), 421-429. doi: 10.1038/ng.113. UCLA: Retrieved from: http://www.escholarship.org/uc/item/7874z8rd |
| DOI: |
10.1038/ng.113. |
| Popis: |
We mapped regulatory loci for nearly all protein-coding genes in mammals using comparative genomic hybridization and expression array measurements from a panel of mouse-hamster radiation hybrid cell lines. The large number of breaks in the mouse chromosomes and the dense genotyping of the panel allowed extremely sharp mapping of loci. As the regulatory loci result from extra gene dosage, we call them copy number expression quantitative trait loci, or ceQTLs. The -2log10P support interval for the ceQTLs was 4, including 13 hotspots each regulating >100 genes in trans. Further, this work identifies 2,761 trans ceQTLs harboring no known genes, and provides evidence for a mode of gene expression autoregulation specific to the X chromosome. © 2008 Nature Publishing Group. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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