Risk factors for human T-cell lymphotropic virus types I and II (HTLV-I and -II) in blood donors: the Retrovirus Epidemiology Donor Study. NHLBI Retrovirus Epidemiology Donor Study
| Autor: | Schreiber, GB, Murphy, EL, Horton, JA, Wright, DJ, Garfein, R, Chien, HC, Nass, CC |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Human T-lymphotropic virus 1 Behavior Deltaretrovirus Infections viruses Human T-lymphotropic virus 2 virus diseases Blood Donors Middle Aged HTLV-I United States HTLV-II sexual transmission injection drug use immune system diseases Risk Factors Virology Multivariate Analysis Humans Female epidemiology Demography transfusion |
| Zdroj: | Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, vol 14, iss 3 |
| Popis: | In the United States, blood donors have been routinely screened for human T-cell lymphotropic virus (HTLV) since 1988. HTLV-I and -II seropositive blood donors have been identified through confirmatory testing at five participating blood centers and frequency-matched seronegative controls provided information on potential HTLV sociodemographic, parenteral, and sexual risk factors during structured interviews. After adjustment, low educational attainment; accidental needlesticks or cuts; prior blood transfusion; > or = 7 sex partners; and a sex partner from an HTLV-I endemic area were significantly associated with both HTLV-I and -II. Gender did not modify the odds ratios (OR) in the final logistic regression models, despite apparent male-female differences in gender-specific bivariable analysis. Injection drug use (IDU) or having sex with an IDUs were significant risks for HTLV-II, but not for HTLV-I. The OR for donors who had IDU sex partners was 20.6 times higher than those who did not. For IDUs, the OR was increased 10.5 times over nonusers. Abortion was a significant HTLV-II risk factor for women. Our findings indicate that IDU and sex with IDUs are important risk factors for HTLV-II transmission, even among low-risk populations such as blood donors. |
| Databáze: | OpenAIRE |
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