Hepatic Steatosis is Negatively Associated with Bone Mineral Density in Children
| Autor: | Chun, Lauren F, Yu, Elizabeth L, Sawh, Mary Catherine, Bross, Craig, Nichols, Jeanne, Polgreen, Lynda, Knott, Cynthia, Schlein, Alexandra, Sirlin, Claude B, Middleton, Michael S, Kado, Deborah M, Schwimmer, Jeffrey B |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Adolescent Chronic Liver Disease and Cirrhosis vitamin D Pediatrics Sampling Studies Paediatrics and Reproductive Medicine Bone Density Non-alcoholic Fatty Liver Disease Clinical Research NAFLD Complementary and Integrative Health Humans 2.1 Biological and endogenous factors Vitamin D Absorptiometry Aetiology Child Nutrition Pediatric Liver Disease Alanine Transaminase gamma-Glutamyltransferase Human Movement and Sports Sciences Magnetic Resonance Imaging Photon osteoporosis osteopenia pediatric Liver Musculoskeletal Biomedical Imaging Osteoporosis Female Digestive Diseases MRI-PDFF |
| Popis: | ObjectiveTo evaluate the relationship between hepatic steatosis and bone mineral density (BMD) in children. In addition, to assess 25-hydroxyvitamin D levels in the relationship between hepatic steatosis and BMD.Study designA community-based sample of 235 children was assessed for hepatic steatosis, BMD, and serum 25-hydroxyvitamin D. Hepatic steatosis was measured by liver magnetic resonance imaging proton density fat fraction (MRI-PDFF). BMD was measured by whole-body dual-energy x-ray absorptiometry.ResultsThe mean age of the study population was 12.5years (SD 2.5years). Liver MRI-PDFF ranged from 1.1% to 40.1% with a mean of 9.3% (SD 8.5%). Across this broad spectrum of hepatic fat content, there was a significant negative relationship between liver MRI-PDFF and BMD z score (R=-0.421, P |
| Databáze: | OpenAIRE |
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