Alanine Aminotransferase and Gamma-Glutamyl Transpeptidase Predict Histologic Improvement in Pediatric Nonalcoholic Steatohepatitis
| Autor: | Newton, Kimberly P, Lavine, Joel E, Wilson, Laura, Behling, Cynthia, Vos, Miriam B, Molleston, Jean P, Rosenthal, Philip, Miloh, Tamir, Fishbein, Mark H, Jain, Ajay K, Murray, Karen F, Schwimmer, Jeffrey B, Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Adolescent Cysteamine Clinical Trials and Supportive Activities Chronic Liver Disease and Cirrhosis Clinical Sciences Immunology Medical Biochemistry and Metabolomics Oral and gastrointestinal Hepatitis Predictive Value of Tests Non-alcoholic Fatty Liver Disease Clinical Research Humans Aspartate Aminotransferases Child Gastroenterology & Hepatology Liver Disease Remission Induction Alanine Transaminase gamma-Glutamyltransferase Prognosis Treatment Outcome Good Health and Well Being Liver Delayed-Action Preparations Nonalcoholic Steatohepatitis Clinical Research Network Female Digestive Diseases |
| Zdroj: | Hepatology (Baltimore, Md.), vol 73, iss 3 |
| Popis: | Background and aimsPredictive, noninvasive tools are needed to monitor key features of nonalcoholic fatty liver disease (NAFLD) in children that relate to improvement in liver histology. The purpose of this study was to evaluate the relationship between liver chemistries and liver histology using data from the CyNCh (Cysteamine Bitartrate Delayed-Release for the Treatment of NAFLD in Children) clinical trial.Approach and resultsThis study included 146 children. Improvement in liver histology, defined as decrease in nonalcoholic fatty liver disease (NAFLD) Activity Score ≥2 points without worsening of fibrosis, occurred in 43 participants (30%). There were 46 participants with borderline zone 1 nonalcoholic steatohepatitis (NASH) at baseline, with resolution in 28% (12 of 46). Multivariate models were constructed using baseline and change in alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT) at 52weeks, for improvement in (1) liver histology primary outcome, (2) borderline zone 1 NASH, and (3) fibrosis. For improvement in histology, the model (P |
| Databáze: | OpenAIRE |
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