In vivo and in vitro sustained release of ranibizumab from a nanoporous thin-film device
| Autor: | Lance, Kevin D, Bernards, Daniel A, Ciaccio, Natalie A, Good, Samuel D, Mendes, Thaís S, Kudisch, Max, Chan, Elliot, Ishikiriyama, Mynna, Bhisitkul, Robert B, Desai, Tejal A |
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| Rok vydání: | 2016 |
| Předmět: |
genetic structures
Polyesters Angiogenesis Inhibitors Bioengineering Electron Nanopores Drug Delivery Systems Ranibizumab Animals Controlled release Scanning Eye Disease and Disorders of Vision Microscopy Pharmacology and Pharmaceutical Sciences eye diseases Vitreous Body Drug Liberation Delayed-Action Preparations Drug delivery Biodegradable Nanoporous Female sense organs Rabbits Fluorescein-5-isothiocyanate Sustained release Biotechnology |
| Zdroj: | Drug delivery and translational research, vol 6, iss 6 |
| Popis: | Current administration of ranibizumab and other therapeutic macromolecules to the vitreous and retina carries ocular risks, a high patient treatment burden, and compliance barriers that can lead to suboptimal treatment. Here we introduce a device that produces sustained release of ranibizumab in the vitreous cavity over the course of several months. Composed of twin nanoporous polymer thin films surrounding a ranibizumab reservoir, these devices provide release of ranibizumab over 16weeks in vitro and 12weeks in vivo, without exhausting the initial drug payload. Following implantation in vivo, devices were well-tolerated and showed no sign of immune response. This platform presents a potential solution to the challenge of delivering protein therapeutics to the vitreous and retina for sustained periods of time. |
| Databáze: | OpenAIRE |
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