Anemia and associated clinical outcomes in patients with heart failure due to reduced left ventricular systolic function
| Autor: | McCullough, Peter A, Barnard, Denise, Clare, Robert, Ellis, Stephen J, Fleg, Jerome L, Fonarow, Gregg C, Franklin, Barry A, Kilpatrick, Ryan D, Kitzman, Dalane W, O'Connor, Christopher M, Piña, Ileana L, Thadani, Udho, Thohan, Vinay, Whellan, David J, HF-ACTION Investigators |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Time Factors Systole Left Kaplan-Meier Estimate Cardiorespiratory Medicine and Haematology Cardiovascular Hemoglobins Young Adult Risk Factors Clinical Research Ventricular Dysfunction Odds Ratio 80 and over Humans Ventricular Function HF-ACTION Investigators Prospective Studies Proportional Hazards Models Aged Heart Failure Rehabilitation Anemia Hematology Middle Aged United States Exercise Therapy Hospitalization Treatment Outcome Heart Disease Good Health and Well Being Cardiovascular System & Hematology Disease Progression Linear Models Female Biomarkers |
| Zdroj: | Clinical cardiology, vol 36, iss 10 |
| Popis: | BackgroundAnemia is associated with decreased functional capacity, reduced quality of life, and worsened outcomes among patients with heart failure (HF) due to reduced left ventricular ejection fraction (HFREF). We sought to evaluate the independent effect of anemia on clinical outcomes among those with HFREF.HypothesisAnemia is associated with cardiovascular events in patients with heart failure.MethodsThe HF-ACTION trial was a prospective, randomized trial of exercise therapy vs usual care in 2331 patients with HFREF. Patients with New York Heart Association class II to IV HF and left ventricular ejection fractions of ≤ 35% were recruited. Hemoglobin (Hb) was measured up to 1 year prior to entry and was stratified by quintile. Anemia was defined as baseline Hb |
| Databáze: | OpenAIRE |
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