Neuronal and glial cell number is altered in a cortical layer-specific manner in autism
| Autor: | Falcone, Carmen, Mevises, Natalie-Ya, Hong, Tiffany, Dufour, Brett, Chen, Xiaohui, Noctor, Stephen C, Martínez Cerdeño, Verónica |
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| Rok vydání: | 2021 |
| Předmět: |
anatomy
Autism Spectrum Disorder Autism Intellectual and Developmental Disabilities (IDD) 1.1 Normal biological development and functioning Cell Count Developmental & Child Psychology Stem Cell Research - Nonembryonic - Human Underpinning research Humans 2.1 Biological and endogenous factors Psychology Autistic Disorder Aetiology Cerebral Cortex Neurons postmortem Pediatric Neurosciences Stem Cell Research Brain Disorders Mental Health Neurological Specialist Studies in Education Stem Cell Research - Nonembryonic - Non-Human Cognitive Sciences Neuroglia |
| Zdroj: | Autism : the international journal of research and practice, vol 25, iss 8 |
| Popis: | Lay abstractThe cerebral cortex affected with autism spectrum disorder presents changes in the number of neurons and glia cells, possibly leading to a dysregulation of brain circuits and affecting behavior. However, little is known about cell number alteration in specific layers of the cortex in autism spectrum disorder. We found an increase in the number of neurons and a decrease in the number of astrocytes in specific layers of the prefrontal cortex in postmortem human brains from autism spectrum disorder cases. We hypothesize that this may be due to a failure in neural stem cells to shift differentiation from neurons to glial cells during prenatal brain development. These data provide key anatomical findings that contribute to the bases of autism spectrum disorder pathogenesis. |
| Databáze: | OpenAIRE |
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