Circulating matrix metalloproteinases in children with diabetic ketoacidosis
| Autor: | Garro, Aris, Chodobski, Adam, Szmydynger-Chodobska, Joanna, Shan, Rongzi, Bialo, Shara R, Bennett, Jonathan, Quayle, Kimberly, Rewers, Arleta, Schunk, Jeffrey E, Casper, T Charles, Kuppermann, Nathan, Glaser, Nicole, Pediatric Emergency Care Applied Research Network (PECARN) |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Glycated Hemoglobin Pediatric cerebral injury Adolescent Diabetes biomarkers Severity of Illness Index Matrix Metalloproteinases Diabetic Ketoacidosis Paediatrics and Reproductive Medicine Endocrinology & Metabolism cerebral edema Clinical Research Case-Control Studies Diabetes Mellitus Humans Fluid Therapy Female Child Pediatric Emergency Care Applied Research Network type 1 diabetes mellitus Metabolic and endocrine Type 1 |
| Zdroj: | Pediatric diabetes, vol 18, iss 2 |
| Popis: | Background and objectiveMatrix metalloproteinases (MMPs) mediate blood-brain barrier dysfunction in inflammatory disease states. Our objective was to compare circulating MMPs in children with diabetic ketoacidosis (DKA) to children with type 1 diabetes mellitus without DKA.Research design and methodsThis was a prospective study performed at five tertiary-care pediatric hospitals. We measured plasma MMP-2, MMP-3, and MMP-9 early during DKA (time 1; within 2 h of beginning intravenous fluids) and during therapy (time 2; median 8 h; range: 4-16 h). The primary outcome was MMP levels in 34 children with DKA vs. 23 children with type 1 diabetes without DKA. Secondary outcomes included correlations between MMPs and measures of DKA severity.ResultsIn children with DKA compared with diabetes controls, circulating MMP-2 levels were lower (mean 77 vs. 244 ng/mL, p |
| Databáze: | OpenAIRE |
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