Genotype-dependent efficacy of a Dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas

Autor: McCormick, Frank, Shoji, K, Oda, K, Kashiyama, T, Ikeda, Y, Nakagawa, S, Sone, K, Miyamoto, Y, Hiraike, H, Tanikawa, M, Miyasaka, A
Jazyk: angličtina
Rok vydání: 2012
Zdroj: McCormick, Frank; Shoji, K; Oda, K; Kashiyama, T; Ikeda, Y; Nakagawa, S; et al.(2012). Genotype-dependent efficacy of a Dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/4vq8054n
Popis: The PI3K (phosphatidylinositol-3-kinase)/mTOR (mammalian target of rapamycin) pathway is frequently activated in endometrial cancer through various PI3K/AKT-activating genetic alterations. We examined the antitumor effect of NVP-BEZ235-a dual PI3K/mTOR inh
Databáze: OpenAIRE