A mutation in desmin makes skeletal muscle less vulnerable to acute muscle damage after eccentric loading in rats
| Autor: | Langer, Henning T, Mossakowski, Agata A, Avey, Alec M, Wohlgemuth, Ross P, Smith, Lucas R, Zbinden-Foncea, Herman, Baar, Keith |
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| Rok vydání: | 2021 |
| Předmět: |
Risk
Male Biochemistry & Molecular Biology injury muscle Physiology Medical Physiology Apoptosis Muscle Fibers Desmin intermediate Genetics Animals 2.1 Biological and endogenous factors Aetiology exercise Animal Skeletal Electric Stimulation Rats filament Musculoskeletal Disease Models Acute Disease Chronic Disease Mutation Female Collagen Biochemistry and Cell Biology signaling Muscle Contraction |
| Zdroj: | FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol 35, iss 9 |
| Popis: | Desminopathy is the most common intermediate filament disease in humans. The most frequent mutation causing desminopathy in patients is a R350P DES missense mutation. We have developed a rat model with an analogous mutation in R349P Des. To investigate the role of R349P Des in mechanical loading, we stimulated the sciatic nerve of wild-type littermates (WT) (n=6) and animals carrying the mutation (MUT) (n=6) causing a lengthening contraction of the dorsi flexor muscles. MUT animals showed signs of ongoing regeneration at baseline as indicated by a higher number of central nuclei (genotype: P |
| Databáze: | OpenAIRE |
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