Tumor-induced solid stress activates β-catenin signaling to drive malignant behavior in normal, tumor-adjacent cells
| Autor: | Ou, Guanqing, Weaver, Valerie Marie |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Psychology and Cognitive Sciences
Bioengineering beta-catenin mechanobiology β-catenin Biological Sciences Stem Cell Research Medical and Health Sciences Colo-Rectal Cancer tumorigenesis Phenotype colon cancer Neoplasms Disease Progression Animals Humans 2.1 Biological and endogenous factors Stem Cell Research - Nonembryonic - Non-Human Aetiology Digestive Diseases beta Catenin Signal Transduction Cancer Developmental Biology |
| Zdroj: | BioEssays : news and reviews in molecular, cellular and developmental biology, vol 37, iss 12 |
| Popis: | Recent work by Fernández-Sánchez and coworkers examining the impact of applied pressure on the malignant phenotype of murine colon tissue in vivo revealed that mechanical perturbations can drive malignant behavior in genetically normal cells. Their findings build upon an existing understanding of how the mechanical cues experienced by cells within a tissue become progressively modified as the tissue transforms. Using magnetically stimulated ultra-magnetic liposomes to mimic tumor growth -induced solid stress, Fernández-Sánchez and coworkers were able to stimulate β-catenin to promote the cancerous behavior of both a normal and genetically modified colon epithelium. In this perspective, we discuss their findings in the context of what is currently known regarding the role of the mechanical landscape in cancer progression and β-catenin as a mechanotransducer. We review data that suggest that mechanically regulated activation of β-catenin fosters development of a malignant phenotype in tissue and predict that mechanical cues may contribute to tumor heterogeneity. |
| Databáze: | OpenAIRE |
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