| Autor: |
GU, YJ, VANOEVEREN, W, AKKERMAN, C, BOONSTRA, PW, HUYZEN, RJ, WILDEVUUR, CRH |
| Jazyk: |
angličtina |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Annals of thoracic surgery, 55(4), 917-922. ELSEVIER SCIENCE INC |
| ISSN: |
0003-4975 |
| Popis: |
Cardiopulmonary bypass generates a systemic inflammatory response including the activation of the complement cascade and leukocytes contributing to postoperative morbidity. To evaluate whether the use of heparin-coated extracorporeal circuits could reduce these activation processes, we performed a study on 30 patients undergoing coronary artery bypass grafting who were randomly perfused with a heparin-coated circuit (Duraflo II, n = 15) or with a similar noncoated circuit (control, n = 15). Standardized systemic heparinization was applied for every patient before cardiopulmonary bypass. The use of heparin-coated circuits resulted in a reduction of systemic leukocyte activation during cardiopulmonary bypass reflected by reduced elastase release (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
