Disease spectrum of patients with antineutrophil cytoplasmic autoantibodies of defined specificity: distinct differences between patients with anti-proteinase 3 and anti-myeloperoxidase autoantibodies

Autor:	Franssen, C, Gans, R, Kallenberg, C, Hageluken, C, Hoorntje, S
Přispěvatelé:	Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Translational Immunology Groningen (TRIGR)
Jazyk:	angličtina
Rok vydání:	1998
Předmět:	myeloperoxidase GLOMERULONEPHRITIS ANTIBODIES ANCA NOMENCLATURE antineutrophil cytoplasmic antoantibodies MYELOID LYSOSOMAL-ENZYMES WEGENERS GRANULOMATOSIS SYSTEMIC VASCULITIS cardiovascular diseases vasculitis proteinase 3
Zdroj:	Journal of Internal Medicine, 244(3), 209-216. Wiley
ISSN:	0954-6820
Popis:	Objective, To compare the disease spectrum of consecutive patients with antineutrophil cytoplasmic autoantibodies directed against proteinase 3 (anti-PR3) or myeloperoxidase (anti-MPO). Design. Retrospective analysis, Setting. Three teaching hospitals in the Netherlands. Main outcome measures, Clinical features at presentation, histopathological characteristics and outcome. Subjects. All consecutive patients who tested positive for anti-PR3 (n = 46) or anti-MPO (n = 46) over an X-year-period. Results, At diagnosis, patients with anti-PR3 had a higher vasculitis activity index than patients with anti-MPO (P
Databáze:	OpenAIRE
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