| Autor: |
Creutzberg, CL, van Putten, WLJ, Koper, PC, Lybeert, MLM, Jobsen, JJ, Warlam-Rodenhuis, CC, De Winter, KAJ, Lutgens, LCHW, van den Bergh, ACM, van der Steen-Banasik, E, Beerman, H, van Lent, M |
| Přispěvatelé: |
Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
| Jazyk: |
angličtina |
| Rok vydání: |
2001 |
| Předmět: |
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| Zdroj: |
International Journal of Radiation Oncology Biology Physics, 51(5), 1246-1255. ELSEVIER SCIENCE INC |
| ISSN: |
0360-3016 |
| Popis: |
Purpose: To compare the treatment complications for patients with Stage I endometrial cancer treated with surgery and pelvic radiotherapy (RT) or surgery alone in a multicenter randomized trial. Methods and Materials: The Postoperative Radiation Therapy in Endometrial Carcinoma (PORTEC) trial included patients with endometrial cancer confined to the uterine corpus, either Grade 1 or 2 with more than 50% myometrial invasion, or Grade 2 or 3 with less than 50% myometrial invasion. Surgery consisted of an abdominal hysterectomy and oophorectomy, without lymphadenectomy. After surgery, patients were randomized to receive pelvic RT (46 Gy), or no further treatment. A total of 715 patients were randomized. Treatment complications were graded using the French-Italian glossary. Results: The analysis was done at a median follow-up duration of 60 months. 691 patients were evaluable. Five-year actuarial rates of late complications (Grades 1-4) were 26% in the RT group and 4% in the control group (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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