| Autor: |
WEYKAMP, CW, PENDERS, TJ, SIEBELDER, CWM, MUSKIET, FAJ, VANDERSLIK, W |
| Přispěvatelé: |
Faculteit Medische Wetenschappen/UMCG, Lifestyle Medicine (LM) |
| Jazyk: |
angličtina |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Clinical Chemistry, 39(1), 138-142. AMER ASSOC CLINICAL CHEMISTRY |
| ISSN: |
0009-9147 |
| Popis: |
In vitro-synthesized carbamylated and acetylated hemoglobins interfered in assays of glycohemoglobin by HPLC and electrophoresis but had no effects on results obtained by affinity chromatography and enzyme immunoassay. Correlations between long-term serum urea concentrations and glycohemoglobin percentages revealed that, in vivo, carbamylated hemoglobin equivalent to 0.063% of total hemoglobin is formed for every 1 mmol/L of serum urea. The use of acetylsalicylate, either chronically in small doses (200-300 mg/day) or for-1 week at 2000 mg/day, did not cause significant interference from acetyl-hemoglobin, formed in vivo. We conclude that interference from carbamylated hemoglobin explains only a small part of existing discrepancies between results of glycohemoglobin assays in current use. The interfering effect of acetylhemoglobin formed in vivo with acetyl-CoA as substrate is as yet unknown. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
