| Autor: |
Leong, SPL, Accortt, NA, Essner, R, Ross, M, Gershenwald, JE, Pockaj, B, Hoekstra, HJ, Garberoglio, C, White, RL, Biel, M, Charney, K, Wanebo, H, Avisar, E, Vetto, J, Soong, SJ |
| Jazyk: |
angličtina |
| Rok vydání: |
2006 |
| Předmět: |
|
| Zdroj: |
ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 132(4), 370-373. AMER MEDICAL ASSOC |
| ISSN: |
0886-4470 |
| Popis: |
Objective: To determine the impact of sentinel lymph node (SLN) status and other risk factors on recurrence and overall survival in head and neck melanoma patients. Design: The SLN Working Group, based in San Francisco, Calif, with its 11 member centers, the John Wayne Cancer Institute, and The University of Texas M. D. Anderson Cancer Center pooled data on 629 primary head and neck melanoma patients who had selective sentinel lymphadenectomy. A total of 614 subjects were analyzable. All centers obtained internal review board approval and adhered to the Health Insurance Portability and Accountability Act of 1996 regulations. A Cox proportional hazards model was used to identify factors associated with overall and disease-free survival. Setting: Tertiary care medical centers. Main Outcome Measure: Clinical outcome of head and neck melanoma patients undergoing selective sentinel lymphadenectomy. Results: Overall, 10.1% (n=62) of the subjects had at least 1 positive node. Subjects with positive SLN status had significantly thicker tumors (mean thickness, 2.8 vs 2.1 mm; P Conclusion: In this multicenter study, SLN status and other risk factors have an effect on recurrence and/or overall survival. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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