| Autor: |
Touw, D.J., Edelbroek, P.M., De Vries, O.J. |
| Přispěvatelé: |
Nanomedicine & Drug Targeting, Biopharmaceuticals, Discovery, Design and Delivery, Groningen Research Institute for Asthma and COPD, Critical care, Anesthesiology, Peri-operative and Emergency medicine, Synthesis and Analysis |
| Jazyk: |
Dutch; Flemish |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
Pharmaceutisch Weekblad, 135(32), 1178-1182. Kon. Ned. Mij. ter Bevordering der Pharmacie (KNMP) |
| ISSN: |
0031-6911 |
| Popis: |
The goal of therapeutic drug monitoring (TDM) is to maximise the effect of drug therapy and to minimise toxicity. TDM is meaningful if on the one hand there is a relationship between the serum concentration of the drug and its effect and on the other hand there is no obvious relationship between dose and efficacy due to wide interindividual variability in pharmacokinetics. In case of digoxin, phenytoin, carbamazepine and valproic acid interindividual pharmacokinetics can vary to such an extent, that drug therapy should be guided by determination of serum drug levels. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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