Activation of angiotensin-converting enzyme expression in infarct zone following myocardial infarction

Autor: Passier, R. C., Smits, J. F., Verluyten, M. J., Studer, R., Drexler, H., Daemen, M. J.
Přispěvatelé: Other departments
Jazyk: angličtina
Rok vydání: 1995
Zdroj: American journal of physiology, 269(4 Part 2), H1268-H1276. American Physiological Society
ISSN: 0002-9513
Popis: In the present study we quantified angiotensin-converting enzyme (ACE) mRNA and localized ACE mRNA and protein in the infarcted rat heart. Wistar rats underwent ligation of the left descending coronary artery, resulting in myocardial infarction (MI) or a sham operation. At different times (1-90 days) after surgery (n = 3 each), the heart was removed and divided into the right ventricle (RV), septum (Se) and left ventricle (LV). ACE mRNA was quantified by competitive reverse transcriptase-polymerase chain reaction (RT-PCR). At 4 and 7 days after MI, we found a 2.8-fold increase of ACE mRNA (n = 3; P
Databáze: OpenAIRE