| Autor: |
Kayali, Ahmed Kandeil, Mounir Abi-Said, Rebecca Badra, Rabeh El-Shesheny, Ahmed A. Al-Karmalawy, Radwan Alnajjar, Zumama Khalid, Mina Nabil Kamel, Walid Abi Habib, Jad Abdallah, Vijaykrishna Dhanasekaran, Richard Webby, Ghazi |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Pathogens; Volume 12; Issue 7; Pages: 876 |
| ISSN: |
2076-0817 |
| DOI: |
10.3390/pathogens12070876 |
| Popis: |
Bats are considered the main reservoir of coronaviruses (CoVs), and research evidence suggests the essential role of bats in the emergence of Severe Acute Respiratory Syndrome Coronaviruses (SARS-CoV) and SARS-CoV-2. SARS-CoV-like viruses have been recently detected in bats in different countries. In 2020, we conducted surveillance for CoVs among six different bat species in Lebanon. Of 622 swab specimens taken, 77 tested positive. Alpha- and Beta- CoVs were identified in samples collected from different species. Our results show that SARS-like coronaviruses circulate in bats in this region, and we provide new data on their genetic diversity. The interaction between the spike of the detected SARS-CoV-like viruses and the human angiotensin-converting enzyme 2 (hACE2) receptor could be crucial in understanding the origin of the epidemic. The 3D protein structure analysis revealed that the receptor-binding domains of the SARS-like virus identified in Lebanon bind to the hACE2 protein more efficiently than to the spike of the SARS-CoV-2 strain. The spike of the detected SARS-CoV-like viruses does not contain the recognition site of furin at the cleavage site. Thus, our study highlights the variety of bat coronaviruses in Lebanon and suggests the zoonotic potential for other SARS-CoV-like viruses. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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