| Autor: |
Soga, Kenji, Arai, Futoshi, Tsuruya, Takashi, Aikawa, Keiko, Toshima, Muneatsu, Shibasaki, Koichi, Aoyagi, Yutaka |
| Jazyk: |
angličtina |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Acta medica et biologica. 41(4):197-200 |
| ISSN: |
0567-7734 |
| Popis: |
In order to diagnose hepatocellular carcinoma (HCC), plasma levels of protein induced by vitamin K absence or antagonist-II (PIVKA-II) were determined by an enzyme-linked immunosorbent assay (ELISA). Positive reaction was noted in 34 (68%) of 50 patients with HCC, with PIVKA-II serving as an useful tumor marker in the estimation of HCC staging. On the other hand, the administration of vitamin K and the presence of jaundice were found to be important factors that affect plasma PIVKA-II levels. The administration of antibiotics with N-methylthiotetrazole at a dosage of 2 g/day for 3 days (total 6 g) did not seem to increase plasma concentrations of PIVKA-II levels. Thus, the measurement of the plasma PIVKA-II levels was useful for the diagnosis of HCC except for the disturbance of vitamin K utilization. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
