Studies on drinking behavior, personality and L-dopa induced hallucination of idiopathic Parkinson's disease patients
| Autor: | Fujii, Chieko |
|---|---|
| Jazyk: | japonština |
| Rok vydání: | 2000 |
| Předmět: | |
| Popis: | The etiology of idiopathic Parkinson's disease(PD) remains unknown although it has been suggested that PD is a multifactorial deisease caused by environmental and genetic risk factors.A number of studies have characterized life styles, psychological traits and clinical symptoms for idiopathic PD.Especially,the tendency to dislike alcohol,the low score of the novelty seeking(NS)and the high score of the harm avoidance(HA)in Tridimensional Personality Questionnaire(TPQ),and individual difference of the occurrence of L-dopa induced hallucination in PD may involve the genetic backgrounds. This study was carried out to confirm the personality characteristic of Caucasian patients by using Japanese patients,and to elucidate the genetic background with specific reference with polymorphism of the ALDH2 and cholecystokinin(CCK)genes. A total of 116 Japanese outpatients with PD diagnosed by three neurologists from 4 hospitals in Kanto area were analyzed for these studies. Among them 93 patients with PD were analyzed for ALDH2 genotypes and alcohol consumption, and 67 Japanese PD patyients were used for TPQ assessments.All patients(116)were analyzed in order to investigate the role of polymorphism of the CCK gene.Age matched control groups(297 subject for ALDH2 genotyping and alcohol consumption,69 subjects for TPQ,and 95 subjects for the CCK gene polimorphism)were analyzed. PCR-SSCP(polymerase chain reaction-single strand conformational change polymorphism)analysis was used to determine ALDH2 and CCK genotypes.Mean values of alcohol consumption(ethanol g/month/person)and TPQ from patients with PD were estimated by direct interview,and those from controls were obtained by questionnaire.The comparison between PD patients and control subjects were analyzed using a chi-square ... 2000 Includes supplementary treatises Includes bibliographical references |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|