| Autor: |
Date, Kazutoshi, Ohtake, Masahiro, Sakaguchi, Takeo, Aono, Takashi, Nihei, Kohei, Tsukada, Kazuhiro, Hatakeyama, Katsuyoshi |
| Jazyk: |
angličtina |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Acta medica et biologica. 43(4):229-232 |
| ISSN: |
0567-7734 |
| Popis: |
Dynamic changes in fatty parameters in the blood and body were examined after 15-deoxyspergualin (DSG) or FK506 (FK) administration in 65% hepatectomized rats. The body composition of fatty parameters, the Lee-index and retroperitoneal white adipose tissue weight (RPWT) were estimated at 0, 1, 3, 5 and 7 days after hepatectomy. The serum total cholesterol concentration (Tch) and other valves including liver and kidney functions were also estimated. DSG 5 mg/kg increased Tch at 3 days after hepatectomy, then returned to the control level within an additional 2 days. On the other hand, RPWT decreased gradually following DSG injection, and a significanct decrease was observed 7 days after hepatectomy. No difference in Lee-index was seen among the groups. The food and water intake over 9 days and body weight gain after hepatectomy were similar among the three groups. DSG and FK increased blood urea nitrogen (BUN) levels compared with the control. Because the doses of agents utilized have been shown to stimulate liver regeneration, our results suggest that DSG at a dose stimulating liver regeneration produces a higher cholesterol level and promotes the catabolism of adipose tissue more slowly and continuously than FK. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
