Granulocyte-Colony Stimulating Factor-Producing Urothelial Carcinoma of Right Renal Pelvis : A Case Report

Autor: Nomura, Yoshihiro, Kobayashi, Maki, Enomoto, Hiroko, Imai, Hiroshi, Wakita, Toshiaki, Yamamoto, Itsuo, Kise, Hideaki
Jazyk: japonština
Rok vydání: 2013
Předmět:
Zdroj: 泌尿器科紀要. 59(11):737-741
ISSN: 0018-1994
Popis: A 78-year-old female patient with fever and general malaise was referred to our hospital. Laboratory examination showed the marked elevation of leukocyte and serum granulocyte-colony stimulating factor (GCSF) concentration without any infectious sign. A computed tomography scan demonstrated irregular enhanced mass of the right kidney with liver metastasis. The pathological findings of the needle biopsy was high-grade urothelial cancer with positive staining for G-CSF antibody. Systemic chemotherapy with gemcitabine and cisplatin was administered. The patient showed a partial response and the serum G-CSF level was normalized after 1 course of chemotherapy. After four courses of chemotherapy, the extent of liver metastasis increased and the G-CSF concentration became elevated. Although combined chemotherapy with paclitaxel and gemcitabine was administered, the patient died 7 months after her first visit.
Databáze: OpenAIRE