Intra-arterial chemotherapy for locally advanced bladder cancer
| Autor: | AOTA, Yasuhiro, YOSHIDA, Kazuhiko |
|---|---|
| Jazyk: | japonština |
| Rok vydání: | 1999 |
| Předmět: | |
| Zdroj: | 泌尿器科紀要. 45(2):149-153 |
| ISSN: | 0018-1994 |
| Popis: | 局所浸潤性膀胱癌83例に対して, CDDPとADR(又はEPIR)動注化学療法を施行した.1990年6月以降の51例には, 放射線療法を併用した. 1)全体の組織学的CR(pCR)は68%, 動注単独群で41%, 放治併用群は84%. 2)全症例の5年生存率は57%, 動注単独群で44%, 放治併用群は71%. 3)全症例での進達度別5年生存率は, T1+T2;82%, T3a;66%, T3b;28%, T4;25%であり, T1+T2とT3b(p A total of 83 patients with locally advanced bladder cancer (T1, n = 5; T2, n = 28; T3a, n = 21; T3b, n = 21; T4, n = 8) were treated with intra-arterial (i.a.) cisplatin and adriamycin (or epirubicin) chemotherapy. In 51 of the 83 cases, we combined this treatment with radiotherapy. The pathological complete response (CR) rate was 68% for all patients, 84% for i.a. chemotherapy combined with radiotherapy and only 41% for i.a. chemotherapy. The 5-year survival rate was 57% for all patients, 71% for i.a. chemotherapy combined with radiotherapy and only 44% for i.a. chemotherapy. The 5-year survival as a function of the clinical stage was 82% for T1 + T2, 66% for T3a, 28% for T3b, 25% for T4 (T1 + T2 vs: T3b: p < 0.001, T1 + T2 vs. T4: p < 0.0001, T3a vs. T3b: p < 0.0263, T3a vs. T4: p < 0.0214, T3b vs. T4: p < 0.029). In 46% of all patients, we succeeded in preserving the bladder; especially noteworthy, is that in 65% of the patients undergoing i.a. chemotherapy combined with radiotherapy, we succeeded in preserving the bladder. These results demonstrate that i.a. chemotherapy combined with radiotherapy is a useful method for locally advanced bladder cancer which may make preservation of the bladder function feasible. |
| Databáze: | OpenAIRE |
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