Hormonal and clinical efficacy of (D-Leu6)-des Gly-NH2(10)-LH.RH ethylamide against prostatic cancer
| Autor: | Imai, Kyoichi, Kumasaka, Fuminari, Kobayashi, Mikio, Suzuki, Takanori, Takahashi, Osamu, Yamanaka, Hidetoshi |
|---|---|
| Jazyk: | japonština |
| Rok vydání: | 1985 |
| Předmět: |
Male
Injections Subcutaneous Follicle Stimulating Hormone/blood Middle Aged Drug Administration Schedule Gonadotropin-Releasing Hormone/administration & dosage/analogs & derivatives/therapeutic use Estradiol/blood Humans Luteinizing Hormone/blood 494.9 Leuprolide Prostatic Neoplasms/blood/drug therapy Antineoplastic Agents/administration & dosage/therapeutic use Dehydroepiandrosterone/blood Testosterone/blood Aged |
| Zdroj: | 泌尿器科紀要. 31(12):2302-2306 |
| ISSN: | 0018-1994 |
| Popis: | 1) TAP 144 1 mg/day連日皮下投与は20 mg/day投与と比較しても, LH, FSH, T.などの血中ホルモンにたいする作用は変らなかった.2) 7例の前立腺癌症例に対してTAP 144 1 mg/day連日皮下投与によって, PR 4例・stable 3例であった.3) TAP 144 1 mg/day 12症例に使用して, あきらかな副作用は認められなかった The hormonal and clinical efficacy of (D-Leu6)-des Gly-NH2(10)-LH.RH ethylamide (Leuprolide, TAP 144) was investigated with 12 prostatic cancer patients. The hormonal studies were performed in 8 patients who were not previously treated by any hormonal therapies including estrogen, castration and others. Serum level of LH and FSH was apparently decreased at the end of 2 weeks after the starting of leuprolide (1 mg/day) subcutaneous injection. At the same time, testosterone level was decreased to the castration level. Clinical efficacy of 1 mg/day of leuprolide was evaluated in 7 patients who were not previously treated. Three of the 4 patients with stage B2 cancer showed a partial response and 1 patient a stable response; and 1 of the 3 patients with stage D2 cancer showed a partial response and patients stable a response. No significant side effects were observed in these 12 patients. These results show that 1 mg/day of leuprolide has the same degree of potency in decreasing the serum testosterone as 20 mg/day. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|