Does the renin-angiotensin system determine the renal and systemic hemodynamic response to sodium in patients with essential hypertension?

Jazyk:	angličtina
Rok vydání:	1996
Předmět:	renal hemodynamics PLASMA BLACK blood pressure remikiren BLOOD-PRESSURE ETIOLOGY renin inhibition KIDNEY SALT-SENSITIVE PATIENTS VOLUME CONVERTING ENZYME-INHIBITION sodium RESTRICTION IDIOPATHIC HYPERTENSION
Zdroj:	Hypertension. 27(2):202-208
ISSN:	1524-4563 0194-911X
Popis:	Many patients with essential hypertension respond to a high dietary sodium intake with a rise in blood pressure. Experimental evidence suggests that the renal hemodynamic response to sodium determines, at least partially, this rise in blood pressure. Our aim was to clarify the role of the renin-angiotensin system in the renal and systemic adaptation to a change in dietary sodium. We studied changes in mean arterial pressure (MAP) (millimeters of mercury), effective renal plasma flow (ERPF), body weight, and immunoreactive renin in 17 patients with essential hypertension and 15 normotensive control subjects, randomly crossing over between a 3-week sodium-restricted (50 mmol/24 h) and a sodium-replete (200 mmol/24 h) diet period. In addition, the effects of renin inhibition by remikiren (600 mg, single oral dose) were studied during the high sodium period. In normotensive control subjects, high sodium intake had no effect on MAP or body weight, whereas ERPF increased (490+/-19 to 535+/-21 mL/min, P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dris___01423::fb20299c7cc728530963e8065bb0f9af https://research.rug.nl/en/publications/6977cb71-0ecd-4c33-8fc9-a08d151a588b Zobrazit plný text záznamu