FAIRification of nanosafety data to improve applicability of (Q)SAR approaches: A case study on Comet assay genotoxicity data
| Jazyk: | angličtina |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
(Quantitative) structure-activity relationship
Registration (Q)SAR approaches Integrated Approaches to Testing and Assessment in vitro Comet assay (Q)SAR NMs SCGE Investigation/Study/Assay Tab-delimited Nano-EHS European Chemicals Agency ECHA Joint Research Centre Interoperable Horizon 2020 Advisory Group for Nanotechnologies Standard Operating Procedures Single Cell Gel Electrophoresis Accessible AOP nanomaterials FAIR NMBP Olive tail moment FAIR principles NANORIGO and RiskGONE MIRCA Adverse Outcome Pathway Findable Advanced Materials Nanosafety data Biotechnology and Advanced Manufacturing and Processing Health and Safety SOPs Fpg Formamido pyrimidine glycosilase NMBP-13-2018 projects Organisation for Economic Co-operation and Development ISA–Tab JRC Gov4Nano OECD Nano Environment REACH IATA Genotoxicity OTM Minimum Information for Reporting Comet Assay and Reusable Evaluation Authorisation and Restriction of Chemicals |
| Popis: | (Quantitative) structure-activity relationship ([Q]SAR) methodologies are widely applied to predict the (eco)toxicological effects of chemicals, and their use is envisaged in different regulatory frameworks for filling data gaps of untested substances. However, their application to the risk assessment of nanomaterials is still limited, also due to the scarcity of large and curated experimental datasets. Despite a great amount of nanosafety data having been produced over the last decade in international collaborative initiatives, their interpretation, integration and reuse has been hampered by several obstacles, such as poorly described (meta)data, non-standard terminology, lack of harmonized reporting formats and criteria. Recently, the FAIR (Findable, Accessible, Interoperable, and Reusable) principles have been established to guide the scientific community in good data management and stewardship. The EU H2020 Gov4Nano project, together with other international projects and initiatives, is addressing the challenge of improving nanosafety data FAIRness, for maximizing their availability, understanding, exchange and ultimately their reuse. These efforts are largely supported by the creation of a common Nanosafety Data Interface, which connects a row of project-specific databases applying the eNanoMapper data model. A wide variety of experimental data relating to characterization and effects of nanomaterials are stored in the database; however, the methods, protocols and parameters driving their generation are not fully mature. This article reports the progress of an ongoing case study in the Gov4nano project on the reuse of in vitro Comet genotoxicity data, focusing on the issues and challenges encountered in their FAIRification through the eNanoMapper data model. The case study is part of an iterative process in which the FAIRification of data supports the understanding of the phenomena underlying their generation and, ultimately, improves their reusability. |
| Databáze: | OpenAIRE |
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