F-box protein Fbxo3 targets Smurf1 ubiquitin ligase for ubiquitination and degradation
| Autor: | Jingyi Shu, Yu-Tao Zhan, Dongnian Li, Fei Zhao, Ping Xie, Li Li, Lingqiang Zhang |
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| Rok vydání: | 2015 |
| Předmět: |
Proteasome Endopeptidase Complex
Protein family Ubiquitin-Protein Ligases Biophysics NEDD4 macromolecular substances Ubiquitin-conjugating enzyme Biochemistry F-box protein SCF complex Ubiquitin Humans Protein Interaction Maps Molecular Biology biology Chemistry F-Box Proteins Ubiquitination Cell Biology Protein ubiquitination Cell biology Ubiquitin ligase HEK293 Cells Bone Morphogenetic Proteins Proteolysis biology.protein Cancer research |
| Zdroj: | Biochemical and biophysical research communications. 458(4) |
| ISSN: | 1090-2104 |
| Popis: | It has been demonstrated previously that F-box protein Fbxl15 targets HECT-type E3 Smurf1 and forms a functionally active SCF complex for ubiquitination and proteasomal degradation. Here we show that another F-box protein Fbxo3, belonging to the FBXO type protein family, also interacts with and targets Smurf1 for poly-ubiquitination and proteasomal degradation. Different from Fbxl15, Fbxo3 targets all the Nedd4 family members for their degradation, indicating that Fbxo3 plays an important role in controlling the stability of Nedd4. Taken together, we show that Smurf1 is an endogenous substrate of Fbxo3. Our study gains further insight into the novel role of Fbxo3 in BMP signaling. |
| Databáze: | OpenAIRE |
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