Ventricular Fibrillation Induced by Ischemia-Reperfusion Is Not Prevented by the NPY Y2 Receptor Antagonist BIIE0246
| Autor: | Trude Aspelin, Morten Eriksen, Jan-Arne Björkman, Arnfinn Ilebekk, Margareta Nordlander, Knut Sevre, Torstein Lyberg |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Swine Ischemia Neuropeptide Blood Pressure Myocardial Reperfusion Myocardial Reperfusion Injury 030204 cardiovascular system & hematology Anterior Descending Coronary Artery Arginine Ventricular tachycardia Body Temperature Norepinephrine (medication) 03 medical and health sciences 0302 clinical medicine Heart Rate Coronary Circulation Internal medicine medicine Animals Pharmacology (medical) cardiovascular diseases 030212 general & internal medicine Cardiac Output Pharmacology business.industry Coronary Stenosis Antagonist Benzazepines Carbon Dioxide Neuropeptide Y receptor medicine.disease Receptors Neuropeptide Y Oxygen Disease Models Animal Hematocrit Ventricular Fibrillation Ventricular fibrillation Potassium Tachycardia Ventricular Cardiology Female Cardiology and Cardiovascular Medicine business Biomarkers medicine.drug |
| Zdroj: | Journal of Cardiovascular Pharmacology and Therapeutics. 11:177-183 |
| ISSN: | 1940-4034 1074-2484 |
| Popis: | Neuropeptide Y is released together with norepinephrine from sympathetic nerve terminals during conditions of increased sympathetic activity. Neuropeptide Y is known to inhibit vagal activity, and accordingly, it might increase the risk for ventricular fibrillation during myocardial ischemia-reperfusion, with concomitant sympathetic stimulation. Counteracting the inhibiting effect of neuropeptide Y by the specific neuropeptide Y2 antagonist, BIIE0246, we expected occurrence of ventricular fibrillation in association with repeated periods of myocardial ischemia-reperfusion to decrease. The midleft anterior descending coronary artery was repeatedly occluded in 16 open-chest pigs. Eight pigs received BIIE0246, and the controls received the vehicle only. Ventricular fibrillation developed in 2 animals of the control group, but in 4 pigs receiving BIIE0246. Occurrence of ventricular fibrillation and ventricular tachycardia did not differ significantly between the 2 groups, and in association with repeated periods of regional myocardial ischemia, did not decline in pigs treated by the specific neuropeptide Y2-receptor antagonist BIIE0246. |
| Databáze: | OpenAIRE |
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