Efficacy of inorganic bovine bone combined with leukocyte and platelet-rich fibrin or collagen membranes for treating unfavorable periodontal infrabony defects: Randomized non-inferiority trial
| Autor: | Imena Rexhepi, Bruna Sinjari, Lorenzo Secondi, Michele Paolantonio, Luigi Romano, Beatrice Femminella, Giulia Paolantonio, Pasquale Santamaria, Matteo Serroni, Paolo De Ninis |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Alveolar Bone Loss Gastroenterology Fibrin law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine Platelet-Rich Fibrin Periodontal Attachment Loss medicine Leukocytes Animals Humans Clinical significance Platelet Gingival recession biology business.industry 030206 dentistry Platelet-rich fibrin Bovine bone 030104 developmental biology biology.protein Guided Tissue Regeneration Periodontal Periodontics Cattle Collagen medicine.symptom Wound healing business |
| Zdroj: | Journal of periodontologyREFERENCES. 92(11) |
| ISSN: | 1943-3670 |
| Popis: | BACKGROUND Growing evidence shows the efficacy of platelet concentrates in periodontal therapy. This study aimed to demonstrate that an inorganic bovine bone graft (IBB) in combination with a leukocyte and platelet rich fibrin (L-PRF) is non-inferior to a combination with a collagen membrane (CM) when managing unfavorable infrabony defects (IBDs). METHODS All patients exhibited at least one unfavorable IBD; they were randomly assigned to two groups, 31 treated with L-PRF+IBB and 31 with CM+IBB. A clinical and radiographic examination was performed at baseline and 12 months later. Clinical attachment level (CAL), gingival recession (GR), probing depth (PD), and radiographic defect bone level (DBL) post-therapy changes were compared between the two treatments. A non-inferiority margin = 1 mm was set to determine the efficacy of the test treatment (-1 mm for GR); a second non-inferiority margin = 0.5 mm (-0.5 mm for GR) was chosen for clinical relevance. RESULTS Twelve months after surgery a significant improvement of clinical and radiographic parameters was observed at both experimental sites. The 90% confidence intervals of the CM+IBB-L-PRF+IBB mean difference for CAL gain (-0.810 mm [-1.300 to -0.319]) and DBL gain (-0.648 mm [-1.244 to -0.052]) were below the 0.5 mm non-inferiority margin; GR increase (1.284 mm [0.764 to 1.804]) remained above the -0.5 mm, while PD reduction (0.499 mm [0.145 to 0.853]) crossed its 0.5-mm margin. CONCLUSIONS The L-PRF+IBB treatment of unfavorable IBDs offers non-inferior efficacy for CAL gain, showing less GR and more DBL gain too, while for PD reduction it is inferior to the CM+IBB treatment. |
| Databáze: | OpenAIRE |
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