Cellular infiltration at skin lesions and draining lymph nodes of sheep infested with adult Hyalomma anatolicum anatolicum ticks
| Autor: | M. B. Manohar, D. G. Raj, S. K. Wikel, J. Lalitha, D. K. V. Boppana |
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| Rok vydání: | 2004 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male Tick infestation Pathology medicine.medical_specialty Ixodidae Lymphocyte Sheep Diseases Biology parasitic diseases medicine Cytotoxic T cell Animals Antigen-presenting cell Lymph node Skin Sheep integumentary system medicine.disease Tick Infestations Cellular infiltration Infectious Diseases medicine.anatomical_structure Immunology Animal Science and Zoology Parasitology Female Lymph Lymph Nodes Infiltration (medical) |
| Zdroj: | Parasitology. 131(Pt 5) |
| ISSN: | 0031-1820 |
| Popis: | Immunohistochemical analysis of skin and draining lymph nodes of sheep repeatedly infested with the ixodid tickHyalomma anatolicum anatolicumwere studied for different antigen-presenting cells and lymphocyte subpopulations. Infiltration of neutrophils, macrophages and lymphocytes adjacent to the tick bite site were observed. Skin biopsies showed significant increases in dermal infiltration of CD8+and γδ+T cells at 72 h and 8 days after both primary and secondary infestation. Infiltrations of MHC-II DR/DQ decreased at 72 h after tick infestation, whereas significant increases were recorded for 8-day skin biopsies. CD1+cellular infiltrations were observed during secondary infestations at the dermis. Decreased ratios of CD4[ratio ]CD8 T cells and MHC-II[ratio ]CD1 antigen-presenting cells were observed in both infestations compared to healthy skin biopsies. Ratios of αβ[ratio ]γδ T cells increased gradually during infestation compared to uninfested skin. The regional lymph nodes from tick-infested sheep showed an increased CD8+, γδ+T and CD1+cellular infiltration compared to control lymph nodes. CD4+T cells were decreased. There were no significant changes in CD45R+cellular infiltration either at skin lesions or regional lymph nodes. |
| Databáze: | OpenAIRE |
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