Effects of plant and animal high protein diets on immune-inflammatory biomarkers: A 6-week intervention trial
| Autor: | Natalia Rudovich, Stephanie Sucher, Rosemarie Schneeweiss, Mariya Markova, Krasimira Aleksandrova, Liselot Koelman, Sascha Rohn, Andreas Pfeiffer, Juergen Machann, Olga Pivovarova, Ralph Thomann, Silke Hornemann |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Adipokine 030209 endocrinology & metabolism Critical Care and Intensive Care Medicine Plant Proteins Dietary 03 medical and health sciences 0302 clinical medicine Insulin resistance Blood serum Adipokines Transforming Growth Factor beta Internal medicine Animal Proteins Dietary medicine Humans Chemerin Aged Inflammation 030109 nutrition & dietetics Nutrition and Dietetics biology business.industry Middle Aged medicine.disease Endocrinology Diabetes Mellitus Type 2 SuPAR Plant protein Diet High-Protein biology.protein Female GDF15 Calprotectin business Leukocyte L1 Antigen Complex Biomarkers |
| Zdroj: | Clinical Nutrition. 39:862-869 |
| ISSN: | 0261-5614 |
| DOI: | 10.1016/j.clnu.2019.03.019 |
| Popis: | Summary Background & aims Pro-inflammatory biomarkers are well-established contributors to insulin resistance and represent valid targets for diabetes management and prevention. Yet, little is known whether nutrition could play a role in modulating various aspects of immune-inflammatory responses. Our aim is to assess the effect of isocaloric animal and plant protein dietary interventions on selected biomarkers representing various immune-inflammatory pathways. Methods We enrolled 37 participants with type 2 diabetes (age 64 ± 6 years, body mass index 30.2 ± 3.6 kg/m2, glycated hemoglobin 7.0 ± 0.6%) who underwent an either high-animal protein (AP) or high-plant protein (PP) diet (30 E% protein, 40 E% carbohydrates, 30 E% fat) for 6-weeks. Clinical examinations were performed at beginning and end of the study. Levels of pro-inflammatory adipokines [chemerin, progranulin], cytokines [tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), soluble urokinase-type plasminogen activator receptor (suPAR), transforming growth factor beta 1 (TGF-β1)], and proteins [calprotectin, lactoferrin and growth differentiation factor 15 (GDF-15)] were determined in blood serum using enzyme-linked immunosorbent assay. Results Chemerin and progranulin concentrations decreased following AP and PP diets. TGF-β1 increased in AP and decreased in PP, whereas calprotectin increased in PP and decreased in AP. No statistically significant differences in the concentrations of IL-6, TNF-α, suPAR, lactoferrin and GDF-15 could be seen in either of the protein diet arms. Conclusions These results suggest that both AP and PP diets may effectively reduce the levels of the pro-inflammatory adipokines chemerin and progranulin. The effects on the additional immune-inflammatory biomarkers seem to be more complex. Clinical trial registry number NCT02402985 ( ww.clinicaltrials.gov ). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect