Effectiveness and residual speed of flea kill of a novel spot on formulation of spinetoram (Cheristin
| Autor: | Anthony J. Rumschlag, William G. Ryan, Joseph Raymond Winkle, Tandy Paarlberg, Daniel E. Snyder, Lisa Marie Young |
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| Rok vydání: | 2016 |
| Předmět: |
Veterinary medicine
Flea Insecticides Time Factors 040301 veterinary sciences Administration Topical 030231 tropical medicine Imidacloprid Biology Cat Diseases 0403 veterinary science 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Flea Infestations Untreated control parasitic diseases Animals Spinetoram Fipronil CATS Research Cheristin 04 agricultural and veterinary sciences Survival Analysis Infectious Diseases Treatment Outcome chemistry Fleas Cats Siphonaptera Parasitology Macrolides Geometric mean After treatment |
| Zdroj: | Parasites & Vectors |
| ISSN: | 1756-3305 |
| Popis: | Background A spot-on spinetoram formulation (Cheristin®) was developed to eliminate fleas from infested cats. This paper describes three spinetoram studies: two for registration (Studies 1 and 2), and one comparing residual speed of kill (SOK) with topically applied fipronil/(S)-methoprene (FSM) and imidacloprid (Study 3). Methods Cats were randomized to treatment based on flea counts from infestations placed within 2 weeks prior to treatment. In Studies 1 and 2, groups were untreated control and spinetoram; in Study 3, groups were untreated control, spinetoram, FSM and imidacloprid, all applied per label on Day 0. Cats were infested the day before treatment. In Studies 1 and 2, counts were completed 48 h post-treatment and after weekly challenges through 5 weeks. In Study 3, infestations were completed weekly through Day 28, with counts 1, 4, 8 and 12 h after treatment or post-infestation (PI). Efficacy was determined on geometric mean flea count reductions compared with controls, and in Study 3 mean flea counts in spinetoram-groups were compared with those in FSM and imidacloprid groups. Results In Studies 1 and 2, spinetoram effectiveness was 100% against existing infestations, and at least 96% through Day 37. In Study 3 mean counts were not significantly different from controls in any group until 8 h post-treatment when imidacloprid counts were significantly lower than spinetoram counts, which were in turn significantly lower than FSM counts (P |
| Databáze: | OpenAIRE |
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