Impact of Fenugreek on Milk Production in Rodent Models of Lactation Challenge
| Autor: | Audrey Aguesse, Blandine Castellano, Clair-Yves Boquien, Patrick Ngyuen, Khadija Ouguerram, Thomas Sevrin, Marie-Cécile Alexandre-Gouabau, Dominique Darmaun |
|---|---|
| Přispěvatelé: | INRA: UMR1280 Physiologie des adaptations (UMR1280), Institut National de la Recherche Agronomique (INRA), Boquien, Clair-Yves |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Litter (animal)
Offspring [SDV]Life Sciences [q-bio] Breastfeeding 030209 endocrinology & metabolism Lactose lcsh:TX341-641 Carbohydrate metabolism Biology Article 03 medical and health sciences 0302 clinical medicine Animal science Alkaloids fenugreek Pregnancy 030225 pediatrics Lactation milk composition medicine Animals Food and Nutrition maternal protein restriction Adverse effect ComputingMilieux_MISCELLANEOUS reproductive and urinary physiology 2. Zero hunger Nutrition and Dietetics Fatty Acids litter size milk flow plasma metabolic parameters Glucose Tolerance Test Milk Proteins Rats medicine.anatomical_structure Milk Trigonella Alimentation et Nutrition Composition (visual arts) Female Breast feeding lcsh:Nutrition. Foods and food supply Biomarkers Food Science |
| Zdroj: | Nutrients Nutrients, MDPI, 2019, 11 (11), pp.2571. ⟨10.3390/nu11112571⟩ Nutrients, Vol 11, Iss 11, p 2571 (2019) Nutrients 11 (11), 1-21. (2019) Volume 11 Issue 11 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu11112571⟩ |
| Popis: | Fenugreek, a herbal remedy, has long been used as galactologue to help mothers likely to stop breastfeeding because of perceived insufficient milk production. However, few studies highlight the efficacy of fenugreek in enhancing milk production. The aims of our study were to determine whether fenugreek increased milk yield in rodent models of lactation challenge and if so, to verify the lack of adverse effects on dam and offspring metabolism. Two lactation challenges were tested: increased litter size to 12 pups in dams fed a 20% protein diet and perinatal restriction to an 8% protein diet with eight pups&rsquo litter, with or without 1 g.kg-1.day-1 dietary supplementation of fenugreek, compared to control dams fed 20% protein diet with eight pups&rsquo litters. Milk flow was measured by the deuterium oxide enrichment method, and milk composition was assessed. Lipid and glucose metabolism parameters were assessed in dam and offspring plasmas. Fenugreek increased milk production by 16% in the litter size increase challenge, resulting in an 11% increase in pup growth without deleterious effect on dam-litter metabolism. Fenugreek had no effect in the maternal protein restriction challenge. These results suggest a galactologue effect of fenugreek when mothers have no physiological difficulties in producing milk. |
| Databáze: | OpenAIRE |
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