Effects of electromyostimulation on muscle and bone in men with acute traumatic spinal cord injury: A randomized clinical trial
| Autor: | Jose Luis R. Martin, José Florensa-Vila, Juan Antonio Godino-Durán, Alfredo Arija-Blázquez, María S. Díaz-Merino, Silvia Ceruelo-Abajo, Luís Martínez-Dhier |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Tetraplegia
Adult Male medicine.medical_specialty Bone density Adolescent Osteoporosis Skeletal muscle Salud Electric Stimulation Therapy Bone and Bones law.invention Médula espinal - Heridas y lesiones Young Adult Randomized controlled trial law Spinal cord injuries medicine Humans Muscle Skeletal Spinal cord injury Research Articles Spinal Cord Injuries Paraplegia Bone mineral Biological markers biology business.industry Middle Aged medicine.disease Surgery Muscular Atrophy Treatment Outcome Anesthesia Acute Disease Osteocalcin biology.protein Electric stimulation Neurology (clinical) business Men's Health |
| Popis: | Objective: To study the effect of 14 weeks of electromyostimulation (EMS) training (47 minutes/day, 5 days/ week) on both muscle and bone loss prevention in persons with recent, complete spinal cord injury (SCI). Design: Prospective, experimental, controlled, single-blind randomized trial with external blind evaluation by third parties. Methods: Eight men with recent SCI (8 weeks from injury; ASIA Impairment Scale (AIS) "A") were randomized into the intervention or the control groups. Cross-sectional area of the quadriceps femoris (QF) muscle was quantified using magnetic resonance imaging. Bone mineral density changes were assessed with a dualenergy X-ray absorptiometry. Several bone biomarkers (i.e. total testosterone, cortisol, growth hormone, insulin-growth factor I, osteocalcin, serum type I collagen C-telopeptide), lipid, and lipoprotein profiles were quantified. A standard oral glucose tolerance test was performed before and after the 14-week training. All analyses were conducted at the beginning and after the intervention. Results: The intervention group showed a significant increase in QF muscle size when compared with the control group. Bone losses were similar in both groups. Basal levels of bone biomarkers did not change over time. Changes in lipid and lipoprotein were similar in both groups. Glucose and insulin peaks moved forward after the training in the intervention group. Conclusions: This study indicates that skeletal muscle of patients with complete SCI retains the ability to grow in response to a longitudinal EMS training, while bone does not respond to similar external stimulus. Increases in muscle mass might have induced improvements in whole body insulin-induced glucose uptake. 1.333 JCR (2014) Q4, posición 152 de 192 (Clinical Neurology) UEM |
| Databáze: | OpenAIRE |
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