Molecular hybridization combining tumor homing and penetrating peptide domains for cellular targeting
| Autor: | Vibin Ramakrishnan, Ruchika Goyal, Aneesh Chandrasekharan, Gaurav Jerath, Yvonne Christian, T. R. Santhosh Kumar |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Chemistry media_common.quotation_subject Pharmaceutical Science Antineoplastic Agents Peptide Cell-Penetrating Peptides In vitro Molecular hybridization Cell biology Drug Delivery Systems Protein Domains Cell Line Tumor Drug delivery Cell-penetrating peptide Tumor homing Internalization Cytotoxicity media_common |
| Zdroj: | Drug Delivery and Translational Research. 12:1285-1292 |
| ISSN: | 2190-3948 2190-393X |
| DOI: | 10.1007/s13346-021-01035-z |
| Popis: | A complete peptide-based drug delivery unit has been designed with a tumor homing domain chemically linked to a syndiotactic cell-penetrating domain. The designed peptides were synthesized, characterized, and tested in vitro for cellular uptake and cytotoxicity evaluation. The differential uptake, cellular internalization, negligible hemotoxicity, selective toxicity to MDA-MB-231 breast cancer cells, and the superior penetration in three-dimensional MDA-MB-231 tumorospheres confirm their utility as a promising delivery vector. |
| Databáze: | OpenAIRE |
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