Bioactive Penicipyrrodiether A, an Adduct of GKK1032 Analogue and Phenol A Derivative, from a Marine-Sourced Fungus Penicillium sp. ZZ380
| Autor: | Lian Xiaoyuan, Mengxuan Chen, Zhi-Wei Ge, Zhizhen Zhang, Tengfei Song, Weiyun Chai, Xing-Cong Li |
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| Rok vydání: | 2018 |
| Předmět: |
Models
Molecular Aquatic Organisms Circular dichroism Macrocyclic Compounds Cell Survival Stereochemistry Antineoplastic Agents medicine.disease_cause Heterocyclic Compounds 4 or More Rings 01 natural sciences Adduct chemistry.chemical_compound Phenols Biosynthesis Cell Line Tumor medicine Humans Phenol Molecular Structure biology 010405 organic chemistry Organic Chemistry Penicillium Glioma biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Staphylococcus aureus Antibacterial activity Derivative (chemistry) |
| Zdroj: | The Journal of Organic Chemistry. 83:13395-13401 |
| ISSN: | 1520-6904 0022-3263 |
| DOI: | 10.1021/acs.joc.8b02172 |
| Popis: | Penicipyrrodiether A, an adduct of GKK1032 analogue and phenol A derivative, was isolated from a culture of marine-associated fungus Penicillium sp. ZZ380 and represents the first example of this type of fungal metabolite. Its structure was elucidated by extensive spectroscopic analyses, including 1D- and 2D-NMR, HRESIMS, MS/MS, and electronic circular dichroism calculation as well as single-crystal X-ray diffraction. Penicipyrrodiether A showed antibacterial activity in inhibiting the growth of methicillin-resistant Staphylococcus aureus with a MIC value of 5.0 μg/mL. Its plausible pathway for biosynthesis has been proposed. |
| Databáze: | OpenAIRE |
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