Action of sodium salicylate on prothrombin time in rabbits
| Autor: | Erica Lepp, L. B. Jaques |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Prothrombin time
Lagomorpha biology medicine.diagnostic_test business.industry Sodium Sodium Salicylate chemistry.chemical_element Pharmacology biology.organism_classification General Biochemistry Genetics and Molecular Biology Salicylates chemistry.chemical_compound chemistry Oral administration Prothrombin Time Medicine Animals Rabbits business Sodium salicylate |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 66(1) |
| ISSN: | 0037-9727 |
| Popis: | SummaryThe effect on the prothrombin time of 12.5% plasma, of oral and intra-venous administration of sodium salicylate, and of dicumarol has been compared in rabbits on a normal diet.The oral and intravenous administration of dicumarol gave the same prolongation of the prothrombin time. However, while the oral administration of 0.5 g/kg of sodium salicylate definitely prolonged the prothrombin time, the intravenous administration of the same dose in the same animal did not result in any change in the prothrombin time. After the oral administration of sodium sulfasuccidine, the oral administration of sodium salicylate did not affect the prothrombin time.It is suggested as an explanation of these results that salicylate may be converted to dicumarol or a substance with similar prothrombinopenic properties by bacterial action in the intestinal tract. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|