The relationship between serum IGF-1, handgrip strength, physical performance and falls in elderly men and women

Autor: I.C. van Nieuwpoort, M C Vlot, Paul Lips, Madeleine L. Drent, Laura A. Schaap
Přispěvatelé: Internal medicine, Epidemiology and Data Science, APH - Aging & Later Life, AGEM - Endocrinology, metabolism and nutrition, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Nutrition and Health, APH - Health Behaviors & Chronic Diseases, Clinical Neuropsychology, IBBA, Amsterdam Movement Sciences
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Risk
medicine.medical_specialty
Aging
Sarcopenia
Cross-sectional study
Endocrinology
Diabetes and Metabolism
030209 endocrinology & metabolism
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Endocrinology
Sex Factors
SDG 3 - Good Health and Well-being
Hand strength
Internal medicine
medicine
Humans
030212 general & internal medicine
Healthy Lifestyle
Longitudinal Studies
Prospective Studies
Insulin-Like Growth Factor I
Prospective cohort study
Exercise
Aged
Netherlands
Aged
80 and over
Hand Strength
business.industry
Confounding
General Medicine
Middle Aged
Growth hormone secretion
Cross-Sectional Studies
Quartile
Physical therapy
Patient Compliance
Observational study
Accidental Falls
Female
Radiology
Psychomotor Disorders
business
Psychomotor Performance
Cohort study
Zdroj: van Nieuwpoort, I C, Vlot, M C, Schaap, L A, Lips, P & Drent, M L 2018, ' The relationship between serum IGF-1, handgrip strength, physical performance and falls in elderly men and women ', European Journal of Endocrinology, vol. 179, no. 2, pp. 73-84 . https://doi.org/10.1530/EJE-18-0076
Van Nieuwpoort, I C, Vlot, M C, Schaap, L A, Lips, P & Drent, M L 2018, ' The relationship between serum IGF-1, handgrip strength, physical performance and falls in elderly men and women ', European Journal of Endocrinology, vol. 179, no. 2, pp. 73-84 . https://doi.org/10.1530/EJE-18-0076
European Journal of Endocrinology, 179(2), 73-84. BioScientifica Ltd.
ISSN: 0804-4643
DOI: 10.1530/EJE-18-0076
Popis: Objective Human aging is accompanied by a decrease in growth hormone secretion and serum insulin-like growth factor (IGF)-1 levels. Also, loss of muscle mass and strength and impairment of physical performance, ending in a state of frailty, are seen in elderly. We aimed to investigate whether handgrip strength, physical performance and recurrent falls are related to serum IGF-1 levels in community-dwelling elderly. Design Observational cohort study (cross-sectional and prospective). Methods We studied the association between IGF-1 and handgrip strength, physical performance and falls in participants of the Longitudinal Aging Study Amsterdam. A total of 1292 participants were included (633 men, 659 women). Serum IGF-1 levels were divided into quartiles (IGF-1-Q1 to IGF-1-Q4). Data on falls were collected prospectively for a period of 3 years. All analyses were stratified for age and physical activity and adjusted for relevant confounders. Results Men with a low physical activity score in IGF-1-Q1 and IGF-1-Q2 of the younger age group had a lower handgrip strength compared to IGF-1-Q4. In younger more active males in IGF-1-Q2 physical performance was worse. Recurrent fallers were less prevalent in older, low active males with low IGF-1 levels. In females, recurrent fallers were more prevalent in older, more active females in IGF-1-Q2. IGF-1 quartile may predict changes in handgrip strength and physical performance in men and women. Conclusions Our results indicate that lower IGF-1 levels are associated with lower handgrip strength and worse physical performance, but less recurrent fallers especially in men. Associations were often more robust in IGF-1-Q2. Future studies on this topic are desirable.
Databáze: OpenAIRE
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