Encapsulated papillary carcinoma with and without frank invasion: Comparison of clinicopathologic features and role of axillary staging
| Autor: | Jonathan D. Marotti, Christopher R. Jackson, Kristen E. Muller, Cameron C Felty, Kari M. Rosenkranz |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Sentinel lymph node Breast Neoplasms 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Breast cancer Nodal status Internal Medicine medicine Humans Neoplasm Staging Sentinel Lymph Node Biopsy Invasive disease business.industry medicine.disease Carcinoma Papillary Oncology Lymphatic Metastasis 030220 oncology & carcinogenesis Axilla embryonic structures cardiovascular system Encapsulated papillary carcinoma Clinicopathological features Female Surgery Lymph Nodes Papillary carcinoma Radiology business Axillary staging circulatory and respiratory physiology |
| Zdroj: | The Breast Journal. 27:209-215 |
| ISSN: | 1524-4741 1075-122X |
| DOI: | 10.1111/tbj.14153 |
| Popis: | To investigate clinical and pathologic features of encapsulated papillary carcinomas (EPCs) that may be associated with invasive disease and characterize the axillary staging practices for EPCs at our institution. A pathology database search for cases containing "papillary carcinoma" was performed. Slides were reviewed by two pathologists. Clinicopathological features and axillary staging practices of EPCs with and without invasion were compared. Twenty-five cases of EPCs were identified. Fifteen cases contained a frank invasive tumor (60%), which were all pT1 (0.7 ± 0.56 cm), and the majority were ER-positive, HER2-negative, low-grade IDC-NST. Seventeen patients underwent sentinel lymph node biopsies (SLNB). No nodal metastases were identified. Follow-up was available for 24 patients (mean = 39 ± 29 months); 23 had no NED. Patients that presented with a self-palpated mass (versus screening) were more likely to have an invasive component; however, no pathologic or radiologic features differentiated EPCs with and without frank invasion. Pathologic and radiologic characteristics did not differentiate EPCs with and without frank invasion. EPCs have an excellent prognosis supported by the notable disease-free survival and negative nodal status in our cohort, which supports the notion that patients with EPCs may forgo axillary staging. |
| Databáze: | OpenAIRE |
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