Postradiotherapy persistent lymphopenia as a poor prognostic factor in patients with cervical cancer receiving radiotherapy: a single-center, retrospective study
| Autor: | Ayumi Taguchi, T. Shimizuguchi, Yujiro Nakajima, Nao Kino, Maki Takao, Kei Ito, Toshiharu Yasugi, Tomoko Kashiyama, Katsuyuki Karasawa, Konan Hara, Akiko Furusawa |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology Adult medicine.medical_specialty medicine.medical_treatment Uterine Cervical Neoplasms Single Center Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Interquartile range Internal medicine Lymphopenia medicine Humans Lymphocyte Count Radiation Injuries Aged Proportional Hazards Models Retrospective Studies Cervical cancer Aged 80 and over Univariate analysis business.industry Hazard ratio Cancer Retrospective cohort study Hematology General Medicine Middle Aged medicine.disease Prognosis Radiation therapy 030104 developmental biology 030220 oncology & carcinogenesis Lymphatic Metastasis Surgery Female Lymph Nodes business |
| Zdroj: | International journal of clinical oncology. 25(5) |
| ISSN: | 1437-7772 |
| Popis: | Radiotherapy (RT) is effective in cervical cancer; radiation-induced lymphopenia correlates with poor survival outcome in several cancer types. We investigated the association of total lymphocyte count (TLC) with survival outcomes in patients with cervical cancer. We retrospectively reviewed 168 patients with cervical cancer initially treated with definitive RT. We obtained clinicopathological data and TLCs before RT and at the end and at 6 months after RT. Patient-, treatment-, and tumor-specific factors were evaluated to determine their predictive values for overall survival. The association of overall and progression-free survivals with lymphopenia at each point was evaluated. Median follow-up duration was 44 (interquartile range: 25–67) months. Median TLCs before RT and at the end and at 6 months after RT were 1625/mm3, 400/mm3, and 800/mm3 (interquartile range: 1270–1930/mm3, 290–550/mm3, and 600–1067/mm3), respectively. For overall survival, in addition to FIGO stage, body mass index, histology, treatment, and presence of para-aortic lymph node metastasis, lymphopenia at 6 months after RT was a poor prognostic factor in multivariate analysis (P = 0.0026; hazard ratio [HR], 3.06; 95% confidence interval [CI]: 1.48–6.33). For progression-free survival, TLCs before and at 6 months after RT were poor prognostic factors in univariate analysis (P = 0.0318 and 0.0081, respectively); however, the latter was the only independent prognostic factor in multivariate analysis (P = 0.0021; HR, 2.67; 95% CI: 1.43–4.99). Post-RT persistent lymphopenia could be a poor prognostic factor for patients with cervical cancer who receive RT. |
| Databáze: | OpenAIRE |
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